41 strange symptoms that can signal a serious disease

So often your lumps, bumps, rashes, and red spots are harmless. Occasionally, they’re a sign of something far more serious. Here’s how to tell the difference.

Your neck looks dirty
A rash-like discolouration called acanthosis nigricans “almost looks like dirt but has a velvety feel,” says Todd Sontag, DO, a family medicine specialist with Orlando Health Physician Associates. He commonly sees it on the back of the neck or in the armpit. This is often a sign of diabetes or insulin resistance. “Patients will come in asking about this rash they can’t get rid of,” he notes. A doctor will order blood tests to check blood sugar levels to make the diagnosis. Meanwhile, find out about 13 conditions you think you have – but probably don't. 

You’re a woman and you’re sprouting chin hairs
This can be a sign of polycystic ovary syndrome, notes Dr. Sontag. “Usually you see just a few hairs, but they’re dark and coarse like a man’s beard,” he notes. The hormonal imbalance may also affect your period and can thus impact your fertility. A look at your medical history and symptoms can point your doctor in the right direction. Here are 15 health myths that make doctors cringe. 

You see blood spots in your eyes
The condition is known as a subconjunctival haemorrhage, and the American Heart Association notes that this is more common with people who have high blood pressure or diabetes. While these conditions don’t cause the spots, the two are linked, they note, which gives you yet another reason to visit the eye doctor every two years. Head here to find out what's new and what's next in the treatment of diabetes.

Your big toe is swollen
You don’t remember stubbing it – and it’s not like you’d forget. You could be looking at an early symptom of gout, which is not only painful but can signal risk for chronic diseases like high blood pressure and kidney disease. A medical history plus examination by your GP can diagnose it. Concerned about high blood pressure? Find out 18 ways to keep your blood pressure in check. 

You have a major hankering for ice
Occasionally, a patient will come see Dr. Sontag and say “all I want to do is eat ice all day,” he notes. That’s a sign of iron-deficiency anaemia. You’ll need a blood workup, and your doc will want to figure out why you’re anaemic – are you losing blood or not making enough? The answer will direct your care, he notes.

Your eyes are bulging
If this is something that seems new – in pictures from last year they look normal – it could be an overactive thyroid, says Dr. Sontag. You may also notice other symptoms like unexplained weight loss or irritability. A thyroid blood test will ID the problem. Iodine treatment can slow your thyroid, and you can manage the issue with thyroid medications. However, Dr. Sontag notes that sometimes thyroid problems are self-limiting and resolve on their own. Here are 9 silent signs of a thyroid problem. 

You’ve gotten shorter
If you’re wondering how your jeans got longer, you could be witnessing one of the silent signs of osteoporosis. As your bones weaken, the vertebrae in your spine begin to compress and you start to lose height. If you’re 3-4 centimetres shorter than you were in your 20s, see your doctor. Here are 10 tips to stave off osteoporosis.

Your urine is cloudy
When you wee, it should be clear and the colour of light lemonade. If it’s darker yellow, you could be dehydrated; when it’s almost clear, you may be too hydrated. But if it’s cloudy or very dark, you could have a bladder stone that’s irritating the wall of your bladder. A physical exam and urinalysis can pinpoint the issue. It can be hard to know what to believe in the ever-changing world of health. Here are 12 health "myths" that turned out to be true. 

Your feet feel like they’re attached to bricks
This could be a sign of rheumatoid arthritis (RA), a condition that hits women more than men and often strikes those between the ages of 20 and 40. Fatigue (with or without joint pain) is another common symptom. Feeling stiff for four weeks warrants a trip to the GP to make sure everything is OK. Want to separate fact from fiction when it comes to arthritis? Head here to find 5 arthritis myths busted. 

Your stools are black
No doubt it’s an alarming sight, and the colour can be a sign of digested blood, in which case your doctor may consider more serious issues like a stomach ulcer or GI cancer. Find out 48 secrets surgeons won't tell you. 

Your stools are green
Yikes! Green poo certainly gets your attention. “This is often some sort of infection, like giardia or salmonella,” says Dr. Sontag. Your doctor will ask whether you’ve been abroad or camped or hiked recently and then consider testing. Find out 10 ways you never knew you were using the toilet wrong. 

Your wee looks pink
Pink or red wee is a sign of blood in your urine. The most likely causes are a urinary tract or kidney infection, but it can also be present in later stages of kidney, bladder or prostate cancer, notes the Mayo Clinic. A urinalysis will be used, in part, to uncover the cause of the bleeding.

Your wee looks like cola
This should set off immediate alarm bells – particularly after an extreme workout or, say, running a marathon. It could be rhabdomyolysis, which happens when muscle tissue breaks down, enters your bloodstream, and causes kidney damage. This serious disease warrants a trip to the ER. Head here to find out about 12 medical conditions that can kill you in 24 hours or less. 

Your mouth is burning
Appropriately called “burning mouth syndrome,” this may be due to damage to pain and taste nerves. You’ll notice a painful burn or tingle in your mouth that’s frequent and sticks around for months. While there’s no test to diagnose this problem, your doctor will do a thorough check to rule out other potential causes and may give you a prescription that can ease your discomfort.

Your leg hurts when you walk
Certainly, the first thing you want to think about would be: Did I injure myself on that hike I took last weekend or did I overdo it running more kilometres than I should? However, if the pain can’t be linked to an injury and it feels like your actual bone is hurting, it may be bone cancer (even if the pain comes and goes). Talk to your doctor about getting a biopsy. 

You wee all the time
Yes, an increase in bathroom visits can be because of a urinary tract infection – though UTIs usually have that tell-tale burn. However, if you wee constantly and have an unquenchable thirst, you may be developing diabetes, notes Dr. Sontag. If you notice that you’re going much more frequently than before or are waking up throughout the night to relieve yourself, talk to your doctor. Head here to learn how to cope with an 'overactive' bladder. 

Your nipples are leaking
Not breastfeeding? Not having sex? Then it may be a condition called galactorrhea. It could be an underlying medical problem like a prolactinoma, a benign tumour on your pituitary gland. While not always harmful on its own, the tumour can lead to irregular periods and interfere with your fertility. Blood tests can help your doctor uncover the underlying cause of your leakage.

You sit down to watch TV and immediately snooze
What seems like a commonplace event – it was a boring show anyway! – can mean something more: Most notably, sleep apnoea. “I diagnose this a few times per week,” Dr. Sontag says. It’s more than an issue of disruptive snoring, he says: “Some patients hold their breath when they sleep for two minutes at a time. You’re not getting enough oxygen throughout the night,” he says. Sleep machines have come a long way; they’re smaller and quieter today. Don’t be afraid to talk to your doctor if you snore, feel unusually tired throughout the day, or your partner says you stop breathing at night. Here are 9 silent signs of sleep apnoea you might have been ignoring.

You wake up exhausted
This can be a sign of restless leg syndrome, or RLS. “You wake up tired because your body has never fully relaxed at night,” says Dr. Sontag. You may also have a strong urge to move your legs that gets worse when you’re sitting down. An evaluation of your medical history and symptoms can help point your GP in the right direction. Here are 13 surprising things that might be causing your sleep woes. 

You gained 10 kilograms this month
Many people blame their weight gain on a sluggish thyroid – after all, this butterfly-shaped gland at the base of your neck helps control your metabolism. But a slow creep in weight is less likely with a malfunctioning thyroid than sudden weight gain – like 10 kilograms in a month – says Dr. Sontag. Either way, your doctor may want to do a thyroid blood test to rule out the condition. Here are 50 health secrets every woman over 50 should know. 

You swallow and something feels stuck
If you frequently feel like food is caught in your throat or find yourself changing the way you eat (like taking baby bites or avoiding certain bulky foods), this may be a sign of oesophageal cancer. A medical history and physical exam can tell your doctor if it’s a possibility. If so, they may order an imaging test to check for cancer.

Your breast skin is nubby like an orange peel
Dimpled skin may be a sign of underlying breast cancer, says Dr. Sontag. “The orange peel look comes from swelling,” he adds and may be caused by inflammatory breast cancer. (The term is called “peau d’orange.”) A physical exam will be up first, and your doctor may examine breast tissue through a mammogram or ultrasound.

You have a lump on your shoulder
Oddly enough, developing a lymph node on the top of your left clavicle can be a sign of stomach cancer, says Dr. Sontag. (This is called Virchow’s node.) If you notice any strange lumps or bumps that have recently appeared, call your doctor. 

You have a lump around your belly button
A soft bulge around this area may be what’s called an umbilical hernia. But you’re right to get it checked out by your doctor: It could also be a lymph node called a Sister Mary Joseph nodule and a sign of underlying cancer, says Dr. Sontag. “Sometimes your body is doing what it should, and it’s OK to have lumps. But any time you notice anything unusual that’s changed, it’s always worth getting checked out,” he says.

You’re bleeding after menopause
Light spotting isn’t anything to be worried about – in fact, it’s often normal. But period-like bleeding warrants a trip to your doctor who may be concerned about uterine cancer. Early diagnosis is key: Women diagnosed in stage 1 have a five-year survival rate of 88 percent.

You have a new spot on your skin
You know to look for changing moles that are irregular in shape, size or colour (learn the ABCDE‘s of skin cancer), but a new one that pops up should raise your suspicion even more. A new study in the Journal of the American Academy of Dermatology found that 70 percent of melanomas arose from a new mole, while only 30 percent sprang from an existing one. Talk to your dermatologist about any new skin spots, and get an annual skin check to make sure your body-wide complexion is in the clear. Head here to find out more on how to recognise melanoma.

You wake up exhausted
This can be a sign of restless leg syndrome, or RLS. “You wake up tired because your body has never fully relaxed at night,” says Dr. Sontag. You may also have a strong urge to move your legs that gets worse when you’re sitting down. An evaluation of your medical history and symptoms can help point your GP in the right direction. Here are 13 surprising things that might be causing your sleep woes. 

You gained 10 kilograms this month
Many people blame their weight gain on a sluggish thyroid – after all, this butterfly-shaped gland at the base of your neck helps control your metabolism. But a slow creep in weight is less likely with a malfunctioning thyroid than sudden weight gain – like 10 kilograms in a month – says Dr. Sontag. Either way, your doctor may want to do a thyroid blood test to rule out the condition. Here are 50 health secrets every woman over 50 should know. 

You swallow and something feels stuck
If you frequently feel like food is caught in your throat or find yourself changing the way you eat (like taking baby bites or avoiding certain bulky foods), this may be a sign of oesophageal cancer. A medical history and physical exam can tell your doctor if it’s a possibility. If so, they may order an imaging test to check for cancer.

Your breast skin is nubby like an orange peel
Dimpled skin may be a sign of underlying breast cancer, says Dr. Sontag. “The orange peel look comes from swelling,” he adds and may be caused by inflammatory breast cancer. (The term is called “peau d’orange.”) A physical exam will be up first, and your doctor may examine breast tissue through a mammogram or ultrasound.

You have a lump on your shoulder
Oddly enough, developing a lymph node on the top of your left clavicle can be a sign of stomach cancer, says Dr. Sontag. (This is called Virchow’s node.) If you notice any strange lumps or bumps that have recently appeared, call your doctor. 

You have a lump around your belly button
A soft bulge around this area may be what’s called an umbilical hernia. But you’re right to get it checked out by your doctor: It could also be a lymph node called a Sister Mary Joseph nodule and a sign of underlying cancer, says Dr. Sontag. “Sometimes your body is doing what it should, and it’s OK to have lumps. But any time you notice anything unusual that’s changed, it’s always worth getting checked out,” he says. 

You’re bleeding after menopause
Light spotting isn’t anything to be worried about – in fact, it’s often normal. But period-like bleeding warrants a trip to your doctor who may be concerned about uterine cancer. Early diagnosis is key: Women diagnosed in stage 1 have a five-year survival rate of 88 percent.

You have a new spot on your skin
You know to look for changing moles that are irregular in shape, size or colour (learn the ABCDE‘s of skin cancer), but a new one that pops up should raise your suspicion even more. A new study in the Journal of the American Academy of Dermatology found that 70 percent of melanomas arose from a new mole, while only 30 percent sprang from an existing one. Talk to your dermatologist about any new skin spots, and get an annual skin check to make sure your body-wide complexion is in the clear. Head here to find out more on how to recognise melanoma.

You’re really bloated
Beyond simply eating too much sushi (hello, soy sauce) or expecting your period any day now, abnormal and uncomfortable bloating can be a sign of ovarian cancer. You may also wee more frequently, grapple with pelvic pain, or experience pain during sex. If your doctor suspects ovarian cancer, they will first run a physical exam to look for things like an enlarged ovary. Here are 12 other reasons why your belly might be bloated.  

Your feet are itching like crazy
Are you pregnant? A liver disease called cholestasis of pregnancy can cause severe, drive-you-batty itching on your hands and feet. It’s rare, but something to watch out for: While mum isn’t at risk (except for the itching), it can be dangerous for the baby; it increases the likelihood of complications like preterm delivery. Inducing labour may be one option your OB/GYN will consider.

Your skin itches all over
There’s another cause for itchy skin not related to pregnancy – liver damage called cirrhosis. As the American Liver Foundation points out, early damage to the organ often carries zero symptoms. Later, sufferers may experience itching or a yellow cast to their skin, called jaundice. Luckily, after diagnosis, you can prevent further damage by eating healthy and exercising.

You’re bleeding after sex
If your first thought is, well, we haven’t done that in a while, hang on: Bleeding after sex isn’t typical. There are a host of potential causes – ranging from vaginal dryness to cervical polyps – but cervical cancer also falls on that list. While it may be frightening, it’s important to bring it up with your GP who will consider a range of causes and work to rule out cervical cancer.

You develop a bulls-eye rash
If you see a red rash in the shape of a bulls-eye popping up on your skin, you should immediately call your doctor. The first thing they’ll check for is Lyme disease. Caused by a tick bite, the disease can also cause more sneaky symptoms like fatigue, lack of focus and a sore throat. While only 70 to 80 percent of people develop a rash, it may also take on various shapes and colours, like multiple rashes or may even have a blue hue. If you notice these symptoms or anything out of the ordinary after spending time outside where Lyme-carrying ticks live, talk to your doctor.

You don’t feel… right
Yep, this is really vague, but weird, vague “something isn’t right” symptoms should set off alarm bells – possibly for a heart attack. Women don’t always get the classic chest pain symptoms of a heart attack; it can manifest as more silent signs like feeling tired or upper back pain. “With anything out of the ordinary that suddenly pops up without a clear explanation, it doesn’t hurt to have a heart attack in the back of your mind,” says Dr. Sontag. Call your doctor or go to the ER. Head here to find out how to take control of your heart health. 

You can’t get rid of those mouth ulcers
With so many symptoms of celiac disease (300!), diagnosis can be difficult. And while GI issues like diarrhoea, constipation and bloating are common, so too are more head-scratching ones like mouth ulcers, reports Beyond Celiac. You may notice these in your cheeks, gums or lips and they can be painful. While it’s not a slam dunk for diagnosis, also watch out for other symptoms of celiac, like mood problems, joint pain and infertility.

You can’t hear well out of one ear
If you’ve been hearing ringing or sounds are muffled in one ear, you may have an acoustic neuroma, a rare, non-cancerous and often slow-growing tumour, according to the Acoustic Neuroma Association. That’s not to say it’s not dangerous. As it grows, it can cause balance problems and even be life-threatening. If your doctor suspects this, an MRI can confirm the diagnosis. Find out more in this guide to keeping your hearing. 

Your eyebrows are thinning
And you thought you just didn’t have to pluck them anymore. Hair loss, including from your eyebrows, can be a sign that your system is working sluggishly thanks to an underactive thyroid (also called hypothyroidism), says Dr. Sontag. Watch out for other symptoms like feeling cold all the time and constipation. Again, your doc will want to run a simple blood test to evaluate the function of your thyroid.

You bruise easily
When you look down, suddenly you see a bunch of discolourations dotting your legs. Have you just been extra clumsy? Maybe, but it can also be leukaemia. Low blood platelet counts can make you more susceptible to bruises, notes the American Cancer Society. Of course, this doesn’t have to be your first worry, but if your doc suspects a problem, they will check your blood cell count before more invasive testing, like taking a bone marrow sample.

You notice a black streak on your nail
The primary place you likely suspect skin cancer is, well, your skin, but it can also appear on the skin of your nailbed, too. Called acral lentiginous melanoma (ALM), this type of skin cancer can look like a dark streak under your nail. If you don’t know what caused it (like smashing your finger in the door) and it’s recently appeared, see a dermatologist for an evaluation. Find out more about this alarming symptom here.

Your sense of smell is dull
If your nose doesn’t perk up to various smells, your ears should perk up to the possibility of increased odds for Alzheimer’s disease, at least according to one new study published in Neurology. Three hundred people who already had a parent with the disease (and thus were considered higher risk) were asked to take scratch-and-sniff tests (scents varied from lemon to gasoline). People who weren’t as sharp odour identifiers also had markers of AD. Of course, this isn’t enough to diagnose you. If you’re worried about your risk, particularly if you have a family history of the disease, talk to your doctor. Find out 13 common illnesses that have been linked to Alzheimer's.

Your child has sudden OCD
Surprisingly, it may be one of several strep throat symptoms. If you have a little one who had a round of strep throat and has suddenly developed obsessive-compulsive tendencies, the culprit may be the group A Streptococcus infection. It’s a condition called PANDAS, or “paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections.” Along with OCD, they may also develop anxiety, aggression or ADHD-like symptoms. It can be a difficult road to diagnosis, but there are several treatment options available. Talk to your child’s paediatrician if you notice an abrupt and alarming change in their behaviour and personality.

You’re sweating through your clothes
Excessive sweating, often on your hands, underarms, or face is called hyperhidrosis. The sweat itself is harmless (though it can be life-altering), but it can also be an indication that an underlying medical condition is responsible for the extreme wetness. Among other causes, like a side effect of medication, non-Hodgkin lymphoma is one of them. Along with the sweat, you may experience fever, weight loss, or shortness of breath. If your doctor thinks it may be lymphoma, they’ll order a biopsy of any enlarged lymph nodes to confirm or rule out the diagnosis.

Your toenails aren’t growing
It may be convenient, but if you can’t remember the last time your toenails needed a trim, it’s time to ensure something else isn’t going on. Slow growing toenails or leg hair, or foot wounds that don’t heal as they should, are all signs of peripheral artery disease (PAD). These are clues that blood flow is having a tough time reaching your lower half because of plaque build-up in these arteries. Tell your doctor about any of these off-kilter symptoms; they may want to check the pulses in your legs to make sure all is functioning as it should. Here are more weird symptoms that could be a sign that you need to see a doctor. 

This article appeared on Reader's Digest.